Can Omega-3 Improve Insulin Sensitivity?

Written by Cassi O'Brien
Reviewed by Kimberly Langdon
featured image for article on how omega-3 improves insulin sensitivity

Do you have insulin issues but aren’t too keen on taking synthetic drugs such as Metformin? Turns out a very popular natural food supplement may actually be the answer to your health issues! Read the entire article to find out if there’s any truth to the claim “omega-3 improves insulin sensitivity.”

What Exactly is Insulin?

Insulin is a hormone produced by beta cells within the pancreas. It’s responsible for utilizing glucose (blood sugar) so that it can be used or stored as the body’s energy source. Since it plays such an important role in keeping the body functioning properly, it can lead to serious health issues if not regulated.

What is Insulin Sensitivity?

Insulin sensitivity is related to how the body metabolizes glucose and stores its energy source. It is most commonly brought up in relation to the topic of diabetes. But insulin sensitivity can be a very complex issue and it may be caused by a variety of factors.

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Treatments for impaired insulin sensitivity are numerous. There are multiple medications for insulin resistance treatment as well as diets for insulin resistance. However, recent studies have shown that a way to help improve insulin sensitivity may also be found within a simple liquid-filled capsule: omega-3 supplements.

Insulin Sensitivity Issues

There are two main forms of insulin sensitivity issues:

High Insulin Sensitivity

Someone with high insulin sensitivity requires less insulin to metabolize glucose and the body tends to produce less insulin than needed. If too much insulin is released or given by injection, this may lead to hypoglycemia, which is a condition of not having enough glucose in the bloodstream.

The most common symptoms of hypoglycemia are shaking and delirium. In severe cases, coma and death may occur as well. However, this is likely due to a tumour called an insulinoma and is very rare or due to too much insulin injected.

Low Insulin Sensitivity

This is the most common type of insulin-related issue and is a hallmark of Type 2 diabetes. It is also known as ‘insulin resistance’. With this condition, the body has difficulty metabolizing glucose because the insulin doesn’t work very well and the pancreas responds by producing more insulin.

This can lead to hyperinsulinemia, which is having too much insulin in the bloodstream. Since there is difficulty with the utilization of glucose, hyperglycemia is also common in those with insulin resistance.

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High blood pressure, cardiac and vascular problems, bone density, and certain cancers are associated with long-term insulin resistance. The factors that cause insulin resistance are undetermined, but the presence of visceral fat is thought to play a significant role.

How Omega-3 Helps Improve Insulin Sensitivity

Omega-3 fatty acids have long been suspected of having the potential to aid those suffering from abnormal insulin sensitivity. But it wasn’t until recent years that the scientific community has conducted solid research into the topic that supports these claims on fish oil insulin interactions.

The mechanism by which omega-3 fatty acids are believed to regulate insulin is by interacting with cell receptors. This interaction allows cells to bind with insulin more easily and may help reverse insulin resistance.

The effects of omega-3 on diabetes and both low and high insulin sensitivity have been studied in the last decade. The conclusions heavily support the effectiveness of omega-3 in improving insulin sensitivity.

Here are a few examples:

  • In a study published in 2007, the possible effect of omega-3 in the prevention of Type 1 diabetes in predisposed children was examined. It found that daily cod oil supplements, which contain both DHA and EPA, were given to study participants during infancy and early childhood. The results of the study showed a reduced risk for the development of Type 1 diabetes in children with a genetic predisposition for it (1).
  • The preventative qualities of omega-3 fatty acids and fish oil are not limited to Type 1 diabetes but have also been seen to improve insulin resistance and prevent the onset of Type 2 diabetes as well. Within a study conducted in 2009, DHA, EPA, and ALA were observed to prevent or reverse insulin resistance (2).
  • The reversal of insulin resistance by omega-3 supplementation may also be possible for pregnant women with gestational diabetes.  A very recent study published in Clinical Nutrition observed that insulin resistance was significantly reduced when study participants were given 1000 mg doses of omega-3 supplements to help treat gestational diabetes. However, blood glucose levels were unchanged (3).

pregnant women can benefit from omega-3 to help improve insulin sensitivityMore Studies on the Benefits of DHA and EPA

Of the three most common omega-3 fatty acids, DHA and EPA have been shown to have the greatest impact on improving insulin resistance. These two fatty acids are found almost exclusive in fish and are the ones contained in omega-3 fish oil supplements.

In the Journal of Nutritional Biochemistry, a study was published that looked at the effects of only DHA.  The study concluded that there was an improvement in those with obesity-related insulin sensitivity when DHA was administered (4).

The effects of EPA on insulin sensitivity in those with Type 2 diabetes were examined in a 2013 doubled-blind and placebo-controlled study published in the Singapore Medical Journal. Participants were given 2 grams of purified EPA daily and a decrease in insulin levels was noticed. This suggests that the pancreas was not triggered to produce excess insulin because insulin resistance was decreased (5).

Omega-3 fatty acids are essential for maintaining health and a deficiency of them may cause a number of health-related issues. A study published in 2012 found that a diet high in fructose but low in omega-3 fatty acids had the potential to disrupt the signalling of insulin receptors in the part of the brain called the hippocampus. This suggests that a possible way to treat insulin resistance and avoid abnormal insulin sensitivity is to maintain a diet that includes omega-3 fatty acids or regularly take omega-3 fish oil supplements before any health issues occur (4).

Conclusion on “Can Omega-3 Improve Insulin Sensitivity?”

As you’ve learned in this article, omega-3 improves insulin sensitivity by treating or reducing insulin resistance. A deficiency in this important nutrient may actually be a significant factor in developing insulin resistance to begin with. So, make sure you get enough omega-3 in your diet. Otherwise, supplementing with high-quality fish oil rich in omega-3 is an excellent alternative. That being said, do check out this article on the 24 ways omega-3 can improve your life!


(1) Norris, Jill M et al. “Omega-3 polyunsaturated fatty acid intake and islet autoimmunity in children at increased risk for type 1 diabetes.” JAMA vol. 298,12 (2007): 1420-8. doi:10.1001/jama.298.12.1420

(2) Fedor, Dawn, and Darshan S Kelley. “Prevention of insulin resistance by n-3 polyunsaturated fatty acids.” Current opinion in clinical nutrition and metabolic care vol. 12,2 (2009): 138-46. doi:10.1097/MCO.0b013e3283218299

(3) Samimi, Mansooreh et al. “Effects of omega-3 fatty acid supplementation on insulin metabolism and lipid profiles in gestational diabetes: Randomized, double-blind, placebo-controlled trial.” Clinical nutrition (Edinburgh, Scotland) vol. 34,3 (2015): 388-93. doi:10.1016/j.clnu.2014.06.005

(4) Oliver E, McGillicuddy FC, Harford KA, et al. Docosahexaenoic acid attenuates macrophage-induced inflammation and improves insulin sensitivity in adipocytes-specific differential effects between LC n-3 PUFA. The Journal of Nutritional Biochemistry. 2012 Sep;23(9):1192-1200. DOI: 10.1016/j.jnutbio.2011.06.014.

(5) Sarbolouki, Shokouh et al. “Eicosapentaenoic acid improves insulin sensitivity and blood sugar in overweight type 2 diabetes mellitus patients: a double-blind randomised clinical trial.” Singapore medical journal vol. 54,7 (2013): 387-90. doi:10.11622/smedj.2013139