The Ultimate Guide To Berberine Supplements

The incidence of insulin resistance, obesity, and other metabolic disorders has reached massive proportions in many nations. While there are various treatments available, some may come with potential side effects. In this article, we’ll do a deep dive into Berberine supplements, a powerful phytonutrient that’s gaining recognition for its ability to naturally support healthy blood sugar levels and metabolic health!

What is Berberine and where does it come from?

Berberine is a plant-based alkaloid compound that is gaining popularity for its natural health benefits. It’s found in plants such as goldenseal, barberry, coptis, Oregon grape, and tree turmeric. ¹

The benefits of berberine are wide-ranging. Its medicinal effects are known in ancient Ayurvedic and Chinese communities. It’s used to treat inflammation, infections, parasites, wounds, ulcers, indigestion, hemorrhoids, and diarrhea. Of course, widespread diabetes is a relatively new health concern. So, past healers didn’t pay much attention to diabetes during ancient times. ²

How exactly does Berberine support metabolic health?

Here are 11 ways that Berberine can benefit you by supporting healthy blood sugar levels and metabolic function:

1) Berberine lowers blood sugar and improves insulin sensitivity

Berberine can help manage blood sugar and improve how your body processes carbs and fats. Here are some key ways it works:

* Berberine supports insulin production in the pancreas

Studies show that Berberine can lower blood sugar levels and improve how your body uses insulin. It may do this by helping the pancreas produce more insulin, allowing your cells to absorb and use sugar for energy. ³

* Activates the “Metabolic Master Switch” enzyme

Berberine activates the AMPK enzyme, which helps regulate your body’s energy and fat use. This enzyme is essential for healthy metabolism, and activating it can help manage weight and blood sugar. ⁴

* Helps break down glucose

Berberine supports glucose breakdown in the body, even when the AMPK enzyme is blocked. This means it has multiple ways of helping to lower blood sugar. ⁵

* Reduces carb and starch digestion

Berberine can also slow down how much your body digests carbs and starches, helping to reduce spikes in blood sugar after meals. ^{6 7}

* Prevents the liver from creating too much glucose

The liver is the main site in the body for making and storing glucose. Berberine helps stop the liver from producing excess glucose, which is especially helpful during fasting or between meals. ⁸

2) Berberine supports healthy metabolism

The same processes that help Berberine manage blood sugar also support how your body handles carbs and fats.

To recap: Berberine reduces glucose production in the liver, slows down carb digestion, and activates the AMPK enzyme, which helps regulate fat and sugar metabolism. It also supports insulin production in the pancreas by helping repair important cells.

3) Berberine supplements may promote weight loss

In one study, people who took 500mg of Berberine 3 times a day for 12 weeks lost an average of 5 pounds (2.3 kg). They also saw reductions in cholesterol and triglyceride levels compared to other weight loss methods. ⁹

Another study, involving people with metabolic syndrome, showed significant weight loss over 3 months. Their BMI dropped from 31.5 (obese) to 27.4 (overweight) with just 300mg of Berberine 3 times a day. Researchers believe this was due to improved insulin resistance. ¹⁰

In a third study, 500mg of Berberine twice daily for 6 months also led to weight loss, while those not taking Berberine actually gained weight. ¹¹

Related article: Will Taking Berberine For Weight Loss Work?

4) May help reduce inflammation

A 2014 study found that Berberine has strong anti-inflammatory effects in both humans and animals with metabolic disorders. This is due to its ability to reduce inflammation and act as an antioxidant. ¹²

5) Berberine helps eliminate bacteria, viruses, and fungi

Berberine not only helps with blood sugar but also has powerful effects against bacteria, viruses, fungi, and parasites. Here are some notable examples:

• Candida overgrowth: Berberine may help fight candida, a fungal infection that starts in the gut and can spread throughout the body. ¹³
• Flu virus: In a rodent study, Berberine reduced the mortality rate of the flu virus from 90% to 55%. ¹⁴
• MRSA bacteria: Berberine may enhance the effectiveness of certain antibiotics against MRSA, a dangerous bacteria resistant to many treatments. ¹⁵

6) It may promote faster wound healing

Berberine may help wounds heal faster, likely due to its antibacterial and anti-inflammatory properties.

7) It promotes heart health and lowers cholesterol

Berberine can help lower high blood sugar, triglycerides, and unhealthy cholesterol levels, which are all risk factors for heart disease. It also helps raise healthy cholesterol. ¹⁶ Additionally, Berberine supplements have been shown to improve survival rates in people who had heart failure. ¹⁷

8) Reduces fat build-up in the liver

Berberine may help reduce fat storage in the liver, which is promising for conditions like non-alcoholic fatty liver disease, although the exact mechanism is still being studied. ¹⁸

9) Berberine supplement may improve mood

In animal studies, rats given Berberine for 15 days showed higher levels of mood-boosting chemicals in the brain like serotonin (19%), dopamine (52%), and norepinephrine (29%). ¹⁹ Another study suggests Berberine may help improve mood, especially in people with mood disorders. ²⁰

10) It encourages good gut bacteria balance

Too much “bad” gut bacteria has been linked to metabolic disorders like type 2 diabetes. ²¹ A poor diet high in processed foods and low in fiber can reduce healthy gut bacteria, which produce anti-inflammatory compounds. ²²

Berberine may help by suppressing harmful bacteria in the gut, while leaving beneficial bacteria, like lactobacillus and bifidobacterium, unaffected. ²³

11) It may help with acne

A study found that adolescents who took 600mg of oral barberry extract (a source of Berberine) for 4 weeks showed significant improvements in their acne. ²⁴

Related article: 14 Amazing Research-Backed Berberine Benefits!

Can Berberine help with type 2 diabetes?

Berberine supplements have gained attention for their ability to help manage blood sugar in people with type 2 diabetes. Let’s look at what some scientific studies say:

Study #1 ²⁵

A 2008 study involving 36 adults with newly diagnosed type 2 diabetes found that Berberine effectively lowered blood sugar levels. It also performed better in improving fat metabolism compared to other common treatments.

In the second part of the study, 48 adults with poorly controlled type 2 diabetes were analyzed. Berberine not only improved blood sugar and cholesterol levels but also helped with fat metabolism. Side effects were mild and temporary, like gas, diarrhea, and constipation. Importantly, there was no harm observed in liver or kidney function.

The study concluded that Berberine could be considered a promising option for managing type 2 diabetes due to its affordability and relatively safe profile.

Study #2 ²⁶

In 2015, researchers conducted a meta-analysis that reviewed 27 clinical trials involving 2,569 patients with type 2 diabetes. Some studies compared Berberine to placebos or lifestyle interventions, while others compared it to medications that lower blood sugar.

The findings were:

• Berberine combined with lifestyle changes was more effective at lowering blood sugar.
• Berberine had a positive effect when combined with other medications.
• Berberine was just as effective as other medicines in lowering blood sugar levels.

Researchers also suggested Berberine as a helpful option for those who may not have access to more expensive medications.

To sum up, Berberine is a natural option for managing type 2 diabetes. It may also help women with PCOS (polycystic ovarian syndrome) manage their symptoms, though there’s currently no cure for PCOS.

Does Berberine have any side effects?

Berberine significantly lowers blood sugar levels with relatively few side effects. In the 2008 study mentioned earlier, some participants taking 500mg three times a day reported minor side effects like gas (19%), abdominal pain (3.4%), diarrhea (10.3%), and constipation (6.9%). Fortunately, these side effects were temporary. ²⁵

It’s important to talk to your doctor before combining Berberine with other blood sugar-lowering substances, as it may cause your blood sugar to drop too low. You should also be cautious when using Berberine with herbs or medications that thin the blood, or if you have a history of low blood pressure.

If you plan to use Berberine to manage a condition like diabetes, consult your doctor first, especially if you’re currently using other drugs or supplements.

Pregnant or breastfeeding women should also consult with their doctor before using Berberine, as it may pose risks to newborns. ¹

Berberine dosage: How much should I take?

Berberine is quickly absorbed by the body but also metabolized fast, so only small amounts remain in the bloodstream after a few hours. To maintain consistent levels, it’s recommended to take Berberine after every meal.

Many studies on people with diabetes suggest a dosage of 500mg three times a day. However, taking more than 500mg at once may lead to side effects like gas or digestive discomfort.

It’s important to choose a high-quality, pure Berberine supplement. Our product is free from wheat, eggs, yeast, soy, sugar, salt, maltodextrin, animal derivatives, magnesium stearate, artificial flavors, and preservatives.

How long does Berberine take to work?

You may start noticing lower blood sugar levels after about a week of use, but it can take three to four weeks for the full effects to show. The time it takes to see benefits can vary depending on what you’re using Berberine for and your individual body.

Where to buy Berberine?

Unfortunately, at this time, our Max Strength Berberine supplement is only available in the USA and Canada. Each capsule contains the clinically recognized 500mg dosage. Our third-party lab testing consistently ensures the purity of the product and the accuracy of the labeling.

Final thoughts

Berberine is a natural compound with many health benefits, including supporting blood sugar and insulin sensitivity. It has a good safety profile with only minor, temporary side effects. In conclusion, Berberine supplements are an effective option for managing health, and scientific studies support its benefits.

This article is for educational purposes and is not a substitute for medical advice. We don’t claim that Berberine can treat or cure diseases, but we aim to provide credible information so you can make informed decisions about your health.

References:

1. Berberine – Uses, Side Effects, and More, taken from: https://www.webmd.com/vitamins/ai/ingredientmono-1126/berberine ↩︎
2. Neag MA, Mocan A, Echeverría J, et al. Berberine: Botanical Occurrence, Traditional Uses, Extraction Methods, and Relevance in Cardiovascular, Metabolic, Hepatic, and Renal Disorders. Front Pharmacol. 2018;9:557. Published 2018 Aug 21. doi:10.3389/fphar.2018.00557 ↩︎
3. Effects and mechanisms of berberine in diabetes treatment, Jun Yin, Jianping Ye, Weiping Jia, Acta Pharmaceutica Sinica B, Volume 2, Issue 4, August 2012, Pages 327-334 ↩︎
4. Winder WW, Hardie DG. AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes. Am J Physiol. 1999;277(1):E1-E10. doi:10.1152/ajpendo.1999.277.1.E1  ↩︎
5. Berberine Promotes Glucose Consumption Independently of AMP-Activated Protein Kinase Activation, Miao Xu, Yuanyuan Xiao et al. PLoS One. 2014; 9(7): e103702.  ↩︎
6. Alpha-Glucosidase Inhibitors for Diabetes, Terri D’Arrigo, Michael Dansinger, MD on May 21, 2023 ↩︎
7. Amylase Inhibitors, taken from: https://www.peacehealth.org/medical-topics/id/hn-3979008 ↩︎
8. Berberine Reduces Pyruvate-driven Hepatic Glucose Production by Limiting Mitochondrial Import of Pyruvate through Mitochondrial Pyruvate Carrier 1, Aiyun Li, Qun Liu et al. EBioMedicine. 2018 Aug; 34: 243–255. ↩︎
9. Hu Y, Ehli EA, Kittelsrud J, et al. Lipid-lowering effect of berberine in human subjects and rats. Phytomedicine. 2012;19(10):861-867. doi:10.1016/j.phymed.2012.05.009 ↩︎
10. Yang J, Yin J, Gao H, et al. Berberine improves insulin sensitivity by inhibiting fat store and adjusting adipokines profile in human preadipocytes and metabolic syndrome patients. Evid Based Complement Alternat Med. 2012;2012:363845. doi:10.1155/2012/363845 ↩︎
11. Seifarth C, Schehler B, Schneider HJ. Effectiveness of metformin on weight loss in non-diabetic individuals with obesity. Exp Clin Endocrinol Diabetes. 2013;121(1):27-31. doi:10.1055/s-0032-1327734 ↩︎
12. Antioxidant and Anti-Inflammatory Activities of Berberine in the Treatment of Diabetes Mellitus, Zheng Li, Ya-Na Geng, Jian-Dong Jiang and Wei-Jia Kong, Evid Based Complement Alternat Med. 2014; 2014: 289264 ↩︎
13. Molecular Mechanisms of Action of Herbal Antifungal Alkaloid Berberine, in Candida albicans, Sanjiveeni Dhamgaye, Frédéric Devaux et al. PLoS One. 2014; 9(8): e104554 ↩︎
14. Wu Y, Li JQ, Kim YJ, Wu J, Wang Q, Hao Y. In vivo and in vitro antiviral effects of berberine on influenza virus. Chin J Integr Med. 2011;17(6):444-452. doi:10.1007/s11655-011-0640-3 ↩︎
15. Yu HH, Kim KJ, Cha JD, et al. Antimicrobial activity of berberine alone and in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus. J Med Food. 2005;8(4):454-461. doi:10.1089/jmf.2005.8.454 ↩︎
16. Dong H, Zhao Y, Zhao L, Lu F. The effects of berberine on blood lipids: a systemic review and meta-analysis of randomized controlled trials. Planta Med. 2013;79(6):437-446. doi:10.1055/s-0032-1328321 ↩︎
17. Zeng XH, Zeng XJ, Li YY. Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol. 2003;92(2):173-176. doi:10.1016/s0002-9149(03)00533-2 ↩︎
18. Berberine in Non-Alcoholic Fatty Liver Disease—A Review, Anna Koperska, Agnieszka Wesołek et al. Nutrients. 2022 Sep; 14(17): 3459. ↩︎
19. Kulkarni SK, Dhir A. On the mechanism of antidepressant-like action of berberine chloride. Eur J Pharmacol. 2008;589(1-3):163-172. doi:10.1016/j.ejphar.2008.05.043 ↩︎
20. Fan J, Zhang K, Jin Y, et al. Pharmacological effects of berberine on mood disorders. J Cell Mol Med. 2019;23(1):21-28. doi:10.1111/jcmm.13930 ↩︎
21. Larsen N, Vogensen FK, van den Berg FW, et al. Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PLoS One. 2010;5(2):e9085. Published 2010 Feb 5. doi:10.1371/journal.pone.0009085 ↩︎
22. Aw W, Fukuda S. Understanding the role of the gut ecosystem in diabetes mellitus. J Diabetes Investig. 2018;9(1):5-12. doi:10.1111/jdi.12673 ↩︎
23. Han J, Lin H, Huang W. Modulating gut microbiota as an anti-diabetic mechanism of berberine. Med Sci Monit. 2011;17(7):RA164-RA167. doi:10.12659/msm.881842 ↩︎
24. Fouladi RF. Aqueous extract of dried fruit of Berberis vulgaris L. in acne vulgaris, a clinical trial. J Diet Suppl. 2012;9(4):253-261. doi:10.3109/19390211.2012.726702 ↩︎
25. Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism. 2008;57(5):712-717. doi:10.1016/j.metabol.2008.01.013 ↩︎
26. Lan J, Zhao Y, Dong F, et al. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. J Ethnopharmacol. 2015;161:69-81. doi:10.1016/j.jep.2014.09.049 ↩︎

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