Glow Naturally With Liposomal Glutathione’s Skin Benefits

Written by Angie Arriesgado
featured image for blog on liposomal glutathione skin benefits

If you don’t want to spend a fortune on skin-lightening treatments and spa appointments to get radiant and clear skin, then read on. In this blog post, we’ll explore how our Liposomal Glutathione – a powerful antioxidant with a long list of benefits – can give your skin a natural, healthy glow. Let’s dive in!

What’s the connection between Glutathione and skin health?

Glutathione (GSH) is often hailed as the body’s master antioxidant. This naturally occurring compound does more than contribute to good health; it’s a key player in achieving healthy-looking skin! It even regenerates other antioxidants like Vitamins C and E.1

GSH is found in every cell, where it combats free radicals that can damage the skin. It contributes to the protection of skin cells from oxidative damage, which is crucial for maintaining skin vitality and appearance.2

Can Glutathione help with skin aging?

Oxidative stress significantly influences skin aging. We all know what this means – wrinkles, fine lines, and loss of skin elasticity. An imbalance between free radicals and antioxidants causes oxidative stress, leading to cellular damage and accelerating the aging process.3

As the body’s main antioxidant, GSH can help mitigate oxidative stress by neutralizing free radicals. GSH’s protective effects help maintain the structural integrity of the skin as well as its firmness and elasticity. Moreover, the ability of GSH to protect against extrinsic aging factors, such as UV radiation, further enhances its role as a key anti-aging skincare ingredient.4

Can Glutathione help improve skin tone?

Yes, Glutathione is an excellent natural option if you want to achieve a more uniform skin complexion without resorting to harsh chemical treatments. It influences skin tone by interacting with melanin, the pigment responsible for skin color.

Researchers found that regular intake of GSH led to a noticeable lightening of skin tone. This effect comes from GSH’s role in inhibiting tyrosinase, an enzyme necessary for melanin production. By reducing melanin synthesis, GSH contributes to a lighter and more even skin tone. Thus making it a popular ingredient in skin-brightening products and treatments.5

Can Glutathione help with hyperpigmentation?

Hyperpigmentation causes dark spots and uneven skin tone. It’s typically not itchy or painful, but it can make the affected individual self-conscious about their ‘spots.’ The culprit? Excessive melanin production.

Fortunately, GSH may be a safe and effective solution for hyperpigmentation. Researchers found it may help reduce the melanin index in the skin, leading to an improved appearance of dark spots and contributing to a more even skin tone.6

Related article: Liposomal Glutathione: An Ultimate Guide To The Body’s Master Antioxidant

liposomal glutathione for skin health

Why is Liposomal Glutathione the best form for skin benefits?

Glutathione is available in different forms – oral, intravenous (IV), topical, etc.

Our Intelligent Labs Liposomal Glutathione is liquid and taken orally. But it differs from standard oral Glutathione, which is poorly absorbed.7 This is because, for liposomal formulations, the GSH is encapsulated within tiny vesicles called ‘liposomes.’ Think of them as tiny bubbles with a robust protective layer that safeguards the GSH within.

This protective layer is made of ‘phosphatidylcholine,’ a key component of our cell membranes. This composition helps the body to absorb the liposomes and, consequently, the Glutathione they carry.8

Liposomes are designed to withstand digestive enzymes, bile salts, and free radicals, ensuring their contents are delivered intact and unharmed.9

Our Liposomal Glutathione is an effective option if you want to enjoy Glutathione’s benefits on skin health. It’s more bioavailable than standard oral GSH. Plus, it’s far more affordable (and safer) than the IV option.

Thanks to its increased bioavailability, your body’s GSH stores increase as well, which may visibly reduce the signs of aging. This reduction is seen in the form of smoother skin, fewer wrinkles, and a more youthful overall appearance!

How much Liposomal Glutathione should you take to enjoy healthy skin?

The typical serving for our liquid Liposomal Glutathione is 5ml, which is about one teaspoon. Each serving contains 500mg of Setria® Glutathione.

However, starting GSH supplementation may activate the body’s detox process, particularly in individuals who previously had low glutathione levels. Because of this, we suggest beginning with a smaller dose of 2.5ml initially (half a teaspoon).  

This detoxification can lead to the removal of accumulated substances in the cells, such as heavy metals. To avoid rapid detoxification, it’s safer to gradually increase the dosage over several days.

That said, taking up to two servings (10ml or 1,000mg of Setria®) per day should still be safe. After all, studies on Setria® Glutathione were conducted using a daily dose of 1000mg,10 indicating that it’s safe to incrementally increase the dosage above 500mg (but do so in 250mg steps). However, if you find that increasing the dose causes any discomfort, it’s important to revert to the lower dosage.

Note: Please consult with your doctor before taking on any new supplement, including our Liposomal Glutathione. They can advise you on the correct dosage for your health needs.

How long should you supplement with Liposomal Glutathione?

Since GSH is a natural substance, you can continue its use as long as you see health benefits. Long-term supplementation at the standard recommended dose is generally considered safe. Numerous studies have reported no significant adverse reactions among participants.

If you choose to discontinue, it’s advisable to gradually reduce the dosage over several days, similar to how you initially increased it. This gradual approach is recommended because optimal Liposomal Glutathione supplementation can decrease the body’s enzymes responsible for producing Glutathione. Therefore, it’s best to lower the dose by 2.5ml every 3 to 4 days.


Our Liposomal Glutathione can be a powerful ally for those looking to achieve optimal skin health (and glow naturally as a result)! Its potent antioxidant properties, coupled with its ability to combat oxidative stress, genuinely make it a valuable addition to your skincare routine.


  1. Pizzorno, Joseph. “Glutathione!” Integrative Medicine (Encinitas, Calif.), vol. 13, no. 1, 1 Feb. 2014, pp. 8–12, ↩︎
  2. Sonthalia, Sidharth, et al. “Glutathione as a Skin Whitening Agent: Facts, Myths, Evidence and Controversies.” Indian Journal of Dermatology, Venereology, and Leprology, vol. 82, no. 3, 2016, p. 262, ↩︎
  3. Silva, Silas Arandas Monteiro e, et al. “An Overview about Oxidation in Clinical Practice of Skin Aging.” Anais Brasileiros de Dermatologia, vol. 92, no. 3, 2017, pp. 367–374, ↩︎
  4. Poljšak, Borut, and Raja Dahmane. “Free Radicals and Extrinsic Skin Aging.” Dermatology Research and Practice, vol. 2012, 2012, pp. 1–4, ↩︎
  5. Weschawalit, Sinee, et al. “Glutathione and Its Antiaging and Antimelanogenic Effects.” Clinical, Cosmetic and Investigational Dermatology, vol. Volume 10, Apr. 2017, pp. 147–153, ↩︎
  6. Handog, Evangeline B., et al. “An Open-Label, Single-Arm Trial of the Safety and Efficacy of a Novel Preparation of Glutathione as a Skin-Lightening Agent in Filipino Women.” International Journal of Dermatology, vol. 55, no. 2, 3 July 2015, pp. 153–157, ↩︎
  7. Allen, Jason, and Ryan D. Bradley. “Effects of Oral Glutathione Supplementation on Systemic Oxidative Stress Biomarkers in Human Volunteers.” The Journal of Alternative and Complementary Medicine, vol. 17, no. 9, Sept. 2011, pp. 827–833, ↩︎
  8. Sinha, R., et al. “Oral Supplementation with Liposomal Glutathione Elevates Body Stores of Glutathione and Markers of Immune Function.” European Journal of Clinical Nutrition, vol. 72, no. 1, 1 Jan. 2018, pp. 105–111, ↩︎
  9. Akbarzadeh, Abolfazl, et al. “Liposome: Classification, Preparation, and Applications.” Nanoscale Research Letters, vol. 8, no. 1, 22 Feb. 2013, ↩︎
  10. Richie, John P., et al. “Randomized Controlled Trial of Oral Glutathione Supplementation on Body Stores of Glutathione.” European Journal of Nutrition, vol. 54, no. 2, 5 May 2014, pp. 251–263, ↩︎